Potentials of Massularia acuminata stem bark extracts on Serum enzymes and haematological parameters of aluminium chloride-induced toxicities

Massularia acuminata is a bioactive herbal plant used to treat many diseases since ancient times. The research work estimates the potential different solvent extracts of Massularia acuminata on serum enzymes and haematological parameters of animals exposed to aluminium chloride. The ethanolic, methanolic and butanolic extracts of this plant were used against aluminium chloride for their hepato-protective effects against aluminium chloride toxicity in Wistar rats with ascorbic acid as standard. The rats were divided into 10 groups with different doses of all the extract, standard and control. The rats were administrated for 30 days under prescribed laboratory conditions. Blood samples were taken through the cardiac puncture, liver organs were harvested and the ALT, AST, ALP, bilirubin and total protein levels were determined to know the effects of Massularia acuminata extracts on liver cells. The results showed a reduction in serum enzymes and aluminium chloride caused a significant decrease in RBC, PCV, Hb, Monocyte and Lymphocyte counts while WBC increased. The results obtained from this study indicate that the solvent extracts of Massularia acuminata have an androgenic potential that can suppress the reproductive toxicity caused by aluminium chloride and could be used in the treatment of infertility This study shows therefore that the extracts from Massularia acuminata may serve as a potent drug against aluminium chloride toxicity.